PEURegen is developing Poraderm, an implantable, degradable, synthetic skin scaffold designed for application in full-thickness deep skin wounds, such as chronic diabetic foot ulcers (DFU) and pressure ulcers (PUs). These two types of ulcers contribute to a 25 billion dollar treatment market alone. Additionally, increases in the number of diabetic patients and the aging population are dramatically escalating the prevalence of DFUs and PUs. The overall goal is to develop and commercialize a cost-effective, high-performance dermal substitute that can treat full-thickness cutaneous wounds in a single application. This would reduce the treatment cost and rate of wound complications, including amputation; ultimately improving both patient health and quality of life. Poraderm is a prefabricated skin graft, made of a porous polymer (polyurethane), which has structural properties similar to those of native skin and can be utilized in medical devices and resorbable scaffolds for tissue regeneration. Poraderm can be manufactured as a three-dimensional, customizable foam that will allow clinicians to completely fill the entire defect in one easy application. Poraderm provides a scaffold for skin regenerating cells to infiltrate, remodel, and replace with healthy skin. Poraderm’s synthetic nature makes it an attractive material in that it has no potential of transmitting infectious diseases, does not induce a prolonged immune response, and subsides regulatory constraints that accompany biologics-based therapies. PEURegen is currently participating in Stage 2 of the E-Team program.